17 results
Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial
- Colleen Loo, Nick Glozier, David Barton, Bernhard T. Baune, Natalie T. Mills, Paul Fitzgerald, Paul Glue, Shanthi Sarma, Veronica Galvez-Ortiz, Dusan Hadzi-Pavlovic, Angelo Alonzo, Vanessa Dong, Donel Martin, Stevan Nikolin, Philip B. Mitchell, Michael Berk, Gregory Carter, Maree Hackett, John Leyden, Sean Hood, Andrew A. Somogyi, Kyle Lapidus, Elizabeth Stratton, Kirsten Gainsford, Deepak Garg, Nicollette L. R. Thornton, Célia Fourrier, Karyn Richardson, Demi Rozakis, Anish Scaria, Cathrine Mihalopoulos, Mary Lou Chatterton, William M. McDonald, Philip Boyce, Paul E. Holtzheimer, F. Andrew Kozel, Patricio Riva-Posse, Anthony Rodgers
-
- Journal:
- The British Journal of Psychiatry / Volume 223 / Issue 6 / December 2023
- Published online by Cambridge University Press:
- 14 July 2023, pp. 533-541
- Print publication:
- December 2023
-
- Article
-
- You have access Access
- Open access
- HTML
- Export citation
-
Background
Prior trials suggest that intravenous racemic ketamine is a highly effective for treatment-resistant depression (TRD), but phase 3 trials of racemic ketamine are needed.
AimsTo assess the acute efficacy and safety of a 4-week course of subcutaneous racemic ketamine in participants with TRD. Trial registration: ACTRN12616001096448 at www.anzctr.org.au.
MethodThis phase 3, double-blind, randomised, active-controlled multicentre trial was conducted at seven mood disorders centres in Australia and New Zealand. Participants received twice-weekly subcutaneous racemic ketamine or midazolam for 4 weeks. Initially, the trial tested fixed-dose ketamine 0.5 mg/kg versus midazolam 0.025 mg/kg (cohort 1). Dosing was revised, after a Data Safety Monitoring Board recommendation, to flexible-dose ketamine 0.5–0.9 mg/kg or midazolam 0.025–0.045 mg/kg, with response-guided dosing increments (cohort 2). The primary outcome was remission (Montgomery-Åsberg Rating Scale for Depression score ≤10) at the end of week 4.
ResultsThe final analysis (those who received at least one treatment) comprised 68 in cohort 1 (fixed-dose), 106 in cohort 2 (flexible-dose). Ketamine was more efficacious than midazolam in cohort 2 (remission rate 19.6% v. 2.0%; OR = 12.1, 95% CI 2.1–69.2, P = 0.005), but not different in cohort 1 (remission rate 6.3% v. 8.8%; OR = 1.3, 95% CI 0.2–8.2, P = 0.76). Ketamine was well tolerated. Acute adverse effects (psychotomimetic, blood pressure increases) resolved within 2 h.
ConclusionsAdequately dosed subcutaneous racemic ketamine was efficacious and safe in treating TRD over a 4-week treatment period. The subcutaneous route is practical and feasible.
A method for controlling for a high placebo response rate in a comparison of venlafaxine XR and diazepam in the short-term treatment of patients with generalised anxiety disorder
- David Hackett, Vincent Haudiquet, Eliseo Salinas
-
- Journal:
- European Psychiatry / Volume 18 / Issue 4 / June 2003
- Published online by Cambridge University Press:
- 16 April 2020, pp. 182-187
-
- Article
- Export citation
-
This randomised, double-blind, placebo-controlled study compared the efficacy of venlafaxine XR (75 or 150 mg/d) with diazepam (15 mg/d) over an 8-week treatment period in 540 non-depressed outpatients with generalised anxiety disorder (GAD). At week 8, significant improvements from baseline were observed in the venlafaxine XR, diazepam and placebo groups. Although these improvements were higher in the first two groups than in the placebo group for each of the primary efficacy variables (Hamilton Rating Scale for Anxiety (HAM-A) total, HAM-A psychic anxiety factor, Hospital Anxiety and Depression Scale (HAD) anxiety sub-scale and Clinical Global Impression (CGI) improvement), there were no statistically significant differences between groups. These non-positive results were thought to be due to the very high placebo response observed in some centres. To understand the variability of the study, a secondary preplanned analysis was performed. This involved sub-dividing the study centres according to their ability to detect a two-point mean difference between diazepam and placebo at week 8 on the HAM-A total score. Centres able to show such a difference were termed verum-sensitive. Improvements from baseline to week 8 in venlafaxine XR-treated patients from verum-sensitive centres were significantly greater than in placebo on each of the primary efficacy measures (P ≤ 0.05). This suggests that those centres able to detect an anxiolytic effect of diazepam were also able to detect an anxiolytic effect of venlafaxine XR. Significant differences in baseline demographics, rates of adverse event reporting and rates of patient discontinuations were noted between patients enrolled at verum-sensitive and verum-insensitive sites. These results reflect the importance of study centre selection in accurately determining efficacy in placebo-controlled trials.
Social adjustment in generalised anxiety disorder: a long-term placebo-controlled study of venlafaxine extended release
- Patrice Boyer, Vincent Mahé, David Hackett
-
- Journal:
- European Psychiatry / Volume 19 / Issue 5 / August 2004
- Published online by Cambridge University Press:
- 16 April 2020, pp. 272-279
-
- Article
- Export citation
-
The objective of this analysis was to evaluate the short- (8 weeks) and long-term (24 weeks) efficacy of three fixed doses of venlafaxine extended release (ER) and placebo on the social adjustment of patients with generalised anxiety disorder (GAD). We analysed data from 544 outpatients who participated in a 24-week, double-blind, multicentre, parallel-group, placebo-controlled study conducted at 55 centres in five countries. All patients meet the DSM-IV criteria for GAD and were randomly assigned to receive venlafaxine ER 37.5, 75, and 150 mg or matched placebo administered orally once daily. Social adjustment was measured using the Social Adjustment Scale-Self Report, which explores social adaptation in the areas of work, social and leisure, extended family, primary relationship (marital), parental, and family unit. At baseline, the GAD patients had a high level of social dysfunction. Venlafaxine ER showed a dose-related improvement in social impairment during short-term treatment and in sustaining this improvement over the long-term. In the most severely socially impaired subgroup, placebo remission rates on the HAM-A were low, and the magnitude of the venlafaxine-placebo difference on the mean HAM-A total score was high, reaching more than 7 points. The benefits of venlafaxine ER treatment of GAD extend beyond that of improvement of anxiety symptoms to a significant improvement in the impairment of functioning that is associated with the illness.
Interference of Horsenettle (Solanum carolinense) with Peanuts (Arachis hypogaea)
- Neil M. Hackett, Don S. Murray, David L. Weeks
-
- Journal:
- Weed Science / Volume 35 / Issue 6 / November 1987
- Published online by Cambridge University Press:
- 12 June 2017, pp. 780-784
-
- Article
- Export citation
-
Duration and density experiments were conducted in the field to measure horsenettle (Solanum carolinense L. # SOLCA) interference with Spanish and runner-type peanuts (Arachis hypogaea L. ‘Pronto’ and ‘Florunner′). Spanish peanut yield generally was higher with 6 to 8 weeks of weed-free maintenance. Horsenettle interference for 6 to 8 weeks did not decrease the yield of Spanish peanuts, and interference for 6 weeks did not decrease yields of runner peanuts. Weed-free maintenance for 2 or more weeks allowed increased runner peanut yield when compared to weedy plots. Linear regression predicted a 69 kg/ha Spanish peanut yield increase for each week of weed-free maintenance. Linear regression predicted a Spanish peanut yield reduction of 40 kg/ha for each week of weed interference in 1983, the only year in which the slopes of the regressions were statistically significant Curvilinear equations with the runner-type cultivar predicted an 81 kg/ha yield increase or 96 kg/ha decrease for each week of weed-free maintenance or weed interference, respectively. In 1 of 2 yr, Spanish peanut yield was reduced by horsenettle at a density of 32 plants/10 m of row.
Interference of Hogpotato (Hoffmanseggia glauca) with Cotton (Gossypium hirsutum)
- Eric P. Castner, Don S. Murray, Neil M. Hackett, Laval M. Verhalen, David L. Weeks, John F. Stone
-
- Journal:
- Weed Science / Volume 37 / Issue 5 / September 1989
- Published online by Cambridge University Press:
- 12 June 2017, pp. 688-694
-
- Article
- Export citation
-
The effects of hogpotato interference on cotton and of the crop on the weed were measured under field conditions in four environments. Full-season interference from 105 ± 21 hogpotato plants/m2 reduced cotton plant height by 14 to 44%. Conversely, weed dry weight was reduced 54% through full-season interference from cotton. Lint yield reductions in cotton ranged from 31 to 98% following full-season weed interference. Interference during the first 7 weeks of crop growth reduced lint yield by approximately 40%; however, interference after 7 weeks of weed-free maintenance did not affect lint yield. Interference reduced boll size in 3 of 4 yr, lint percent in 2 of 4, and boll number in the only year it was measured. Cotton fiber length, uniformity index, and micronaire were reduced by full-season interference in 1 of 2 yr; however, fiber strength was not affected in either year. Significant use of soil water by hogpotato occurred at 120 cm and deeper in the soil while cotton used water primarily in the upper 75 cm.
Symposium Introduction: The Politics of Religious Alliances
- Ursula Hackett, David E. Campbell
-
- Journal:
- Politics and Religion / Volume 9 / Issue 2 / June 2016
- Published online by Cambridge University Press:
- 18 April 2016, pp. 227-233
-
- Article
- Export citation
-
This symposium examines the politics of religious alliances. While the literature on religion and politics generally focuses on differences across individuals, congregations, denominations, or traditions, these articles instead ask how, when, and why religious groups do — and do not — form alliances with other organizations, both religious and secular. Specifically, this collection of original research examines the formation of multi-denominational coalitions among party activists, litigants, and religious leaders. These varied articles arose from a workshop at Oxford University in March 2015, an event hosted and funded by the Rothermere American Institute. The collection explores the impact of religious coalitional activity upon political attitudes, decision-making, and public policy development. It is wide-ranging, extending our understanding of religious coalitional activity beyond the United States and dealing with topics of vital current significance, including the swiftly changing landscape of school voucher and tax credit expansion, same-sex marriage, healthcare, and abortion advocacy.
Contributors
-
- By Michael P. Alexander, Jean-Marie Annoni, Pascal Auzou, Philippe Azouvi, Sandra Black, Stephan Bohlhalter, Thomas Busigny, Lara Caeiro, Hugues Chabriat, Laurent Cohen, Alexandre Croquelois, Luc Defebvre, Stanislas Dehaene, Sebastian Dieguez, Diane Dupuy, José M. Ferro, Olivier Godefroy, Georg Goldenberg, Vladimir Hachinski, Maree Hackett, Hilde Hénon, Argye E. Hillis, Pierre Krolak-Salmon, Pierre Krystkowiak, Mansur A. Kutlubaev, Jany Lambert, Bernard Lechevalier, Claire Leclercq, Didier Leys, Chun Lim, Marie-Anne Mackowiak, Isabel P. Martins, Eugene Mayer, Gillian E. Mead, José G. Merino, Reto Meuli, Paige Moorhouse, Sylvain Moreau, David Nyenhuis, Florence Pasquier, Anne Peskine, Bertille Périn, Hervé Platel, Abid Qureshi, Marc D. Reichhart, Kenneth Rockwood, Bruno Rossion, Martine Roussel, Arnaud Saj, Donald T. Stuss, Pierre Thomas, Tim Vanbellingen, Fausto Viader, Alain Vighetto, Patrik Vuilleumier
- Edited by Olivier Godefroy
-
- Book:
- The Behavioral and Cognitive Neurology of Stroke
- Published online:
- 05 March 2013
- Print publication:
- 28 February 2013, pp vii-x
-
- Chapter
- Export citation
Adult congenital heart disease interventions: recommendations from a Joint Working Group of the British Congenital Cardiac Association, British Cardiovascular Intervention Society, and the British Cardiovascular Society
- Shakeel A. Qureshi, David Hildick-Smith, Jo de Giovanni, Paul Clift, Graham Stuart, Rob Henderson, Stephen Brecker, David Hackett, Simon Ray, Mark de Belder
-
- Journal:
- Cardiology in the Young / Volume 23 / Issue 1 / February 2013
- Published online by Cambridge University Press:
- 15 May 2012, pp. 68-74
-
- Article
- Export citation
-
In order to optimise care of the adult patients with complex congenital heart disease, there is a need to develop recommendations for interventions. This document is the work of representatives of the three relevant societies and provides recommendations for institutions and operators performing cardiac interventions in these patients.
Contributors
-
- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. Douglas Meeks, Monica Jyotsna Melanchthon, Ilie Melniciuc-Puica, Everett Mendoza, Raymond A. Mentzer, William W. Menzies, Ina Merdjanova, Franziska Metzger, Constant J. Mews, Marvin Meyer, Carol Meyers, Vasile Mihoc, Gunner Bjerg Mikkelsen, Maria Inêz de Castro Millen, Clyde Lee Miller, Bonnie J. Miller-McLemore, Alexander Mirkovic, Paul Misner, Nozomu Miyahira, R. W. L. Moberly, Gerald Moede, Aloo Osotsi Mojola, Sunanda Mongia, Rebeca Montemayor, James Moore, Roger E. Moore, Craig E. Morrison O.Carm, Jeffry H. Morrison, Keith Morrison, Wilson J. Moses, Tefetso Henry Mothibe, Mokgethi Motlhabi, Fulata Moyo, Henry Mugabe, Jesse Ndwiga Kanyua Mugambi, Peggy Mulambya-Kabonde, Robert Bruce Mullin, Pamela Mullins Reaves, Saskia Murk Jansen, Heleen L. Murre-Van den Berg, Augustine Musopole, Isaac M. T. Mwase, Philomena Mwaura, Cecilia Nahnfeldt, Anne Nasimiyu Wasike, Carmiña Navia Velasco, Thulani Ndlazi, Alexander Negrov, James B. Nelson, David G. Newcombe, Carol Newsom, Helen J. Nicholson, George W. E. Nickelsburg, Tatyana Nikolskaya, Damayanthi M. A. Niles, Bertil Nilsson, Nyambura Njoroge, Fidelis Nkomazana, Mary Beth Norton, Christian Nottmeier, Sonene Nyawo, Anthère Nzabatsinda, Edward T. Oakes, Gerald O'Collins, Daniel O'Connell, David W. Odell-Scott, Mercy Amba Oduyoye, Kathleen O'Grady, Oyeronke Olajubu, Thomas O'Loughlin, Dennis T. Olson, J. Steven O'Malley, Cephas N. Omenyo, Muriel Orevillo-Montenegro, César Augusto Ornellas Ramos, Agbonkhianmeghe E. Orobator, Kenan B. Osborne, Carolyn Osiek, Javier Otaola Montagne, Douglas F. Ottati, Anna May Say Pa, Irina Paert, Jerry G. Pankhurst, Aristotle Papanikolaou, Samuele F. Pardini, Stefano Parenti, Peter Paris, Sung Bae Park, Cristián G. Parker, Raquel Pastor, Joseph Pathrapankal, Daniel Patte, W. Brown Patterson, Clive Pearson, Keith F. Pecklers, Nancy Cardoso Pereira, David Horace Perkins, Pheme Perkins, Edward N. Peters, Rebecca Todd Peters, Bishop Yeznik Petrossian, Raymond Pfister, Peter C. Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. Rubenstein, Rosemary Radford Ruether, Markku Ruotsila, John E. Rybolt, Risto Saarinen, John Saillant, Juan Sanchez, Wagner Lopes Sanchez, Hugo N. Santos, Gerhard Sauter, Gloria L. Schaab, Sandra M. Schneiders, Quentin J. Schultze, Fernando F. Segovia, Turid Karlsen Seim, Carsten Selch Jensen, Alan P. F. Sell, Frank C. Senn, Kent Davis Sensenig, Damían Setton, Bal Krishna Sharma, Carolyn J. Sharp, Thomas Sheehan, N. Gerald Shenk, Christian Sheppard, Charles Sherlock, Tabona Shoko, Walter B. Shurden, Marguerite Shuster, B. Mark Sietsema, Batara Sihombing, Neil Silberman, Clodomiro Siller, Samuel Silva-Gotay, Heikki Silvet, John K. Simmons, Hagith Sivan, James C. Skedros, Abraham Smith, Ashley A. Smith, Ted A. Smith, Daud Soesilo, Pia Søltoft, Choan-Seng (C. S.) Song, Kathryn Spink, Bryan Spinks, Eric O. Springsted, Nicolas Standaert, Brian Stanley, Glen H. Stassen, Karel Steenbrink, Stephen J. Stein, Andrea Sterk, Gregory E. Sterling, Columba Stewart, Jacques Stewart, Robert B. Stewart, Cynthia Stokes Brown, Ken Stone, Anne Stott, Elizabeth Stuart, Monya Stubbs, Marjorie Hewitt Suchocki, David Kwang-sun Suh, Scott W. Sunquist, Keith Suter, Douglas Sweeney, Charles H. Talbert, Shawqi N. Talia, Elsa Tamez, Joseph B. Tamney, Jonathan Y. Tan, Yak-Hwee Tan, Kathryn Tanner, Feiya Tao, Elizabeth S. Tapia, Aquiline Tarimo, Claire Taylor, Mark Lewis Taylor, Bishop Abba Samuel Wolde Tekestebirhan, Eugene TeSelle, M. Thomas Thangaraj, David R. Thomas, Andrew Thornley, Scott Thumma, Marcelo Timotheo da Costa, George E. “Tink” Tinker, Ola Tjørhom, Karen Jo Torjesen, Iain R. Torrance, Fernando Torres-Londoño, Archbishop Demetrios [Trakatellis], Marit Trelstad, Christine Trevett, Phyllis Trible, Johannes Tromp, Paul Turner, Robert G. Tuttle, Archbishop Desmond Tutu, Peter Tyler, Anders Tyrberg, Justin Ukpong, Javier Ulloa, Camillus Umoh, Kristi Upson-Saia, Martina Urban, Monica Uribe, Elochukwu Eugene Uzukwu, Richard Vaggione, Gabriel Vahanian, Paul Valliere, T. J. Van Bavel, Steven Vanderputten, Peter Van der Veer, Huub Van de Sandt, Louis Van Tongeren, Luke A. Veronis, Noel Villalba, Ramón Vinke, Tim Vivian, David Voas, Elena Volkova, Katharina von Kellenbach, Elina Vuola, Timothy Wadkins, Elaine M. Wainwright, Randi Jones Walker, Dewey D. Wallace, Jerry Walls, Michael J. Walsh, Philip Walters, Janet Walton, Jonathan L. Walton, Wang Xiaochao, Patricia A. Ward, David Harrington Watt, Herold D. Weiss, Laurence L. Welborn, Sharon D. Welch, Timothy Wengert, Traci C. West, Merold Westphal, David Wetherell, Barbara Wheeler, Carolinne White, Jean-Paul Wiest, Frans Wijsen, Terry L. Wilder, Felix Wilfred, Rebecca Wilkin, Daniel H. Williams, D. Newell Williams, Michael A. Williams, Vincent L. Wimbush, Gabriele Winkler, Anders Winroth, Lauri Emílio Wirth, James A. Wiseman, Ebba Witt-Brattström, Teofil Wojciechowski, John Wolffe, Kenman L. Wong, Wong Wai Ching, Linda Woodhead, Wendy M. Wright, Rose Wu, Keith E. Yandell, Gale A. Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
-
- Book:
- The Cambridge Dictionary of Christianity
- Published online:
- 05 August 2012
- Print publication:
- 20 September 2010, pp xi-xliv
-
- Chapter
- Export citation
Forum: American Religion and Class
- David G. Hackett, Laurie F. Maffly-Kipp, R. Laurence Moore, Leslie Woodcock Tentler
-
- Journal:
- Religion and American Culture / Volume 15 / Issue 1 / Winter 2005
- Published online by Cambridge University Press:
- 18 June 2018, pp. 1-29
- Print publication:
- Winter 2005
-
- Article
- Export citation
Adaptación social y trastorno de ansiedad generalizada: un estudio a largo plazo controlado con placebo de la venlafaxina de liberación prolongada
- Patrice Boyer, Vincent Mahé, David Hackett
-
- Journal:
- European Psychiatry (Ed.Española) / Volume 11 / Issue 8 / November 2004
- Published online by Cambridge University Press:
- 12 May 2020, pp. 500-507
- Print publication:
- November 2004
-
- Article
- Export citation
-
El objetivo de este análisis era evaluar la eficacia a corto (8 semanas) y largo plazo (24 semanas) de tres dosis fijas de venlafaxina de liberación prolongada (LP) y placebo en la adaptación social de los pacientes contrastorno de ansiedad generalizada (TAG). Analizamos los datos de 544 pacientes ambulatorios que participant en un estudio multicéntrico doble ciego de grupos paralelos controlado con placebo de 24 semanas realizado en 55 centros en cinco países. Todos los pacientes cumplían los criterios del DSM-IV para TAG y se asignaron aleatoriamente para recibir 37,5, 75 y 150 mg de venlafaxina LP o placebo emparejado administrado oralmente una vez al día. La adaptación social se midió utilizando la Escala de Adaptación Social-Autoinforme, que explora la adaptación social en las áreas laboral, social y de ocio, familia extensa, relación primaria (matrimonial), parental y unidad familiar. En la línea de base, los pacientes con TAG tenían un nivel alto de disfunción social. La venlafaxina LP mostró una mejoría relacionada con la dosis en el deterioro social durante el tratamiento a corto plazo y en el mantenimiento de esta mejoria a largo plazo. En el subgrupo con deterioro social mas importante, las tasas de remisión con el placebo en la HAM-A fueron bajas, y la magnitud de la diferencia venlafaxina-placebo en la puntuación total media de la HAM-A fue alta, alcanzando más de 7 puntos. Los beneficios del tratamiento de venlafaxina LP del TAG se extienden más alia de la mejoría de los síntomas de ansiedad, a una mejoría significativa en el deterioro del funcionamiento que se asocia con la enfer medad.
Un método para controlar una tasa alta de respuesta al placebo en una comparación de venlafaxina XR y diacepam en el tratamiento a corto plazo de pacientes con trastorno de ansiedad generalizada
- David Hackett, Vincent Haudiquet, Eliseo Salinas
-
- Journal:
- European Psychiatry (Ed.Española) / Volume 10 / Issue 7 / October 2003
- Published online by Cambridge University Press:
- 12 May 2020, pp. 430-437
- Print publication:
- October 2003
-
- Article
- Export citation
-
Objetivo
Este estudio doble ciego distribuido al azar y controlado con placebo comparó la eficacia de la venlafaxina XR (75 ó 150 mg/día) con el diacepam (15 mg/día) durante un periodo de tratamiento de 8 semanas en 540 pacientes ambulatorios no deprimidos con trastorno de ansiedad generalizada (TAG). En la semana 8, se observaron mejorías significativas desde la línea de base en los grupos de venlafaxina XR, diacepam y placebo. Aunque estas mejorías eran más altas en los dos primeros grupos que en el de placebo para cada una de las variables primarias de eficacia (total de la Escala de Evaluación de Hamilton para la Ansiedad [HAM-A], factor de ansiedad psíquica de la HAM-A, subescala de ansiedad de la Escala Hospitalaria de Ansiedad y Depresión [HAD] e Impresión Clínica Global [CGI] de la mejoría) no hubo diferencias estadísticamente significativas entre los grupos. Se pensó que estos resultados no positivos se debían a la respuesta muy alta al placebo observada en algunos centros. Para comprender la variabilidad del estudio, se realizó un análisis secundario planeado previamente. Éste implicaba subdividir los centros de estudio según su capacidad para detectar una diferencia media de dos puntos entre el diacepam y el placebo en la semana 8 en la puntuación total de la HAM-A. Los centros que pudieron mostrar esta diferencia se denominaron verdaderamente sensibles. Las mejorías desde la línea de base hasta la semana 8 en los pacientes tratados con venlafaxina XR de los centros verdaderamente sensibles fueron significativamente mayores que en el grupo de placebo en cada una de las medidas de eficacia primaria (P < 0,05). Esto indica que los centros que podían detectar un efecto ansiolítico del diacepam podían también detectar un efecto ansiolítico de la venlafaxina XR. Se advirtieron diferencias significativas en las características demográficas de la línea de base, las tasas de informe de acontecimientos adversos y las tasas de interrupción de los pacientes entre los pacientes inscritos en los sitios verdaderamente sensibles y en los verdaderamente insensibles. Estos resultados reflejan la importancia de la selección de centros de estudio al determinar con precisión la eficacia en los ensayos controlados con placebo.
Venlafaxine Extended Release (ER) in the Treatment of Generalised Anxiety Disorder: Twenty-four-week placebo-controlled dose-ranging study
- Christer Allgulander, David Hackett, Eliseo Salinas
-
- Journal:
- The British Journal of Psychiatry / Volume 179 / Issue 1 / July 2001
- Published online by Cambridge University Press:
- 02 January 2018, pp. 15-22
- Print publication:
- July 2001
-
- Article
-
- You have access Access
- HTML
- Export citation
-
Background
Generalised anxiety disorder (GAD) has received less study than other anxiety disorders, particularly its long-term treatment.
AimsTo assess the efficacy and safety of venlafaxine extended release (ER) in patients with GAD.
MethodA total of 541 out-patients, 18–86 years old, were recruited to this 24-week, placebo-controlled, double-blind study of three fixed doses (37.5, 75 and 150 mg/day) of venlafaxine ER.
ResultsAll doses of venlafaxine ER showed efficacy superior to placebo, apparent from week 2, that was sustained throughout the 24-week study for the two higher doses. The discontinuation rate did not differ significantly among the treatment groups.
ConclusionsVenlafaxine ER is an effective and safe treatment for GAD for up to 6 months.
The Prince Hall Masons and the African American Church: The Labors of Grand Master and Bishop James Walker Hood, 1831–1918
- David G. Hackett
-
- Journal:
- Church History / Volume 69 / Issue 4 / December 2000
- Published online by Cambridge University Press:
- 28 July 2009, pp. 770-802
- Print publication:
- December 2000
-
- Article
- Export citation
-
During the late nineteenth century, James Walker Hood was bishop of the North Carolina Conference of the African Methodist Episcopal Zion Church and grand master of the North Carolina Grand Lodge of Prince Hall Masons. In his forty-four years as bishop, half of that time as senior bishop of the denomination, Reverend Hood was instrumental in planting and nurturing his denomination's churches throughout the Carolinas and Virginia. Founder of North Carolina's denominational newspaper and college, author of five books including two histories of the AMEZ Church, appointed assistant superintendent of public instruction and magistrate in his adopted state, Hood's career represented the broad mainstream of black denominational leaders who came to the South from the North during and after the Civil War. Concurrently, Grand Master Hood superintended the southern jurisdiction of the Prince Hall Masonic Grand Lodge of New York and acted as a moving force behind the creation of the region's black Masonic lodges—often founding these secret male societies in the same places as his fledgling churches. At his death in 1918, the Masonic Quarterly Review hailed Hood as “one of the strong pillars of our foundation.” If Bishop Hood's life was indeed, according to his recent biographer, “a prism through which to understand black denominational leadership in the South during the period 1860–1920,” then what does his leadership of both the Prince Hall Lodge and the AMEZ Church tell us about the nexus of fraternal lodges and African American Christianity at the turn of the twentieth century?
Gender and Religion in American Culture, 1870-1930
- David G. Hackett
-
- Journal:
- Religion and American Culture / Volume 5 / Issue 2 / Summer 1995
- Published online by Cambridge University Press:
- 18 June 2018, pp. 127-157
- Print publication:
- Summer 1995
-
- Article
- Export citation
-
Since the early 1980's, advances in the study of gender in American history have come primarily through an unmasking of the assumptions of earlier studies. Some have questioned the explanatory power of the field's dominant interpretive paradigm, that of “women's sphere,” because this theoretical lens has often led historians to mistake what was said by and about women for their actual historical experience. Others have laid bare the earlier scholarship's assumption of universal gender definitions that do not take into account differences in women's roles based on race, class, or region. Additionally, several historians have begun to explore the influence of gender relations on the lives of men. As a result, we are beginning to get a picture of gender in American history that goes beyond the “women's sphere” experience of white, middle-class, northeastern women.
Nutritional intake, height and weight of 11–12-year-old Northumbrian children in 1990 compared with information obtained in 1980
- Ashley Adamson, Andrew Rugg-Gunn, Timothy Butler, David Appleton, Allan Hackett
-
- Journal:
- British Journal of Nutrition / Volume 68 / Issue 3 / November 1992
- Published online by Cambridge University Press:
- 09 March 2007, pp. 543-563
- Print publication:
- November 1992
-
- Article
-
- You have access Access
- Export citation
-
There is little age-specific information on changes in dietary intake over time in this country, yet this is valuable in assessing the effectiveness of health education programmes particularly in vulnerable groups such as adolescents. In 1990, 379 children aged 12 years completed two 3 d dietary records. They were interviewed by one dietitian on the day after completion of each diary to verify and enlarge on the information provided and, with the aid of food models, obtain a quantitative record of food intake. Nutrient intake was calculated using computerized food tables. These children attended the same seven Middle schools in Northumberland as 405 children of the same age who recorded their diet using the same method, 10 years previously. Heights and weights were also recorded in both studies in the same manner. Comparing the nutrient intakes in 1990 with 1980, energy intake fell in the boys (to 8.6 MJ) but not in the girls (8.3 MJ). The contribution of fat to energy intake was unchanged at about 40% (about 90 g/d). Likewise, intake of sugars was unchanged at about 22% of energy (about 118 g/d). Calcium intake remained the same in the girls (763 mg/d in 1990) but fell in the boys (786 mg/d in 1990). Iron, vitamin C and unavailable carbohydrate intakes increased in both sexes, and the nutrient density of the diet improved in all sex and social-class groups. However, a social trend evident in 1980 still existed in 1990 with low social groups having the poorest-quality diet. It is concluded that there is little evidence of substantial progress towards improving the diet of adolescents in this country.
Sugars-eating habits of 405 11- to 14-year-old English children
- Allan F. Hackett, Andrew J. Rugg-Gunn, David R. Appleton, Marion Allinson, John E. Eastoe
-
- Journal:
- British Journal of Nutrition / Volume 51 / Issue 3 / May 1984
- Published online by Cambridge University Press:
- 09 March 2007, pp. 347-356
- Print publication:
- May 1984
-
- Article
-
- You have access Access
- Export citation
-
1. Between September 1979 and July 1981, 405 northern-English children, initially aged 11–12 years, each recorded all food and drink consumed on five occasions on each of three consecutive days. Sugars and nutrient intakes were calculated using food tables.
2. The average total sugars intake was 118 g/d or 21% of the energy in take and 43% of the carbohydrate intake; these percentages were similar for both sexes, all social class groups and surveys.
3. Sugars were found to be derived from a variety of food sources with confectionery being the single largest source.
4. Sugars were fairly evenly consumed over the average day with a high amount in foods eaten between meals. Snacks accounted for 65% of the sugars intake but only 46% of the energy intake.
5. Sugars intake and snacking therefore seem to have been major components of the eating habits of these children. If dietary changes towards lower sugars intakes are to be achieved a vigorous, informed health education campaign is necessary together with effective labelling of manufactured foods, the development of new products and the modification of some existing ones.